Bilateral retinal detachment after chimeric antigen receptor T-cell therapy
Christopher Denton, William S. Gange, Hisham Abdel‐Azim, Sonata Jodele, Neena Kapoor, Matthew J. Oberley, Kenneth Wong, Jonathan Kim, Abby Vercio, Parisah Moghaddampour, K V Chalam, David Sierpina, Rebecca Gardner, Michael A. Pulsipher, Michael C. Jensen, Aaron Nagiel
Abstract
Key Points CAR T-cell targeting of leukemic infiltrates in the optic nerve and retina caused retinal detachment as a presentation of pseudoprogression. Treatment of this intraocular inflammation with intravitreal triamcinolone and orbital radiation led to marked improvement in visual acuity.
Topics & Concepts
MedicineRetinaRetinal detachmentRetinalOptic nerveChimeric antigen receptorOphthalmologyVisual acuityTriamcinolone acetonideCell therapyPresentation (obstetrics)ImmunotherapyCellSurgeryImmunologyNeuroscienceBiologyImmune systemGeneticsCAR-T cell therapy researchNanowire Synthesis and ApplicationsVirus-based gene therapy research