FKBP5/FKBP51 on weight watch: central FKBP5 links regulatory WIPI protein networks to autophagy and metabolic control
Thomas Bajaj, Alexander S. Häusl, Mathias V. Schmidt, Nils C. Gassen
Abstract
: AKT: thymoma viral proto-oncogene; AMPK: AMP-activated protein kinase; BECN1: beclin 1, autophagy related; eWAT: epididymal white adipose tissue; FKBP5/FKBP51: FK506 binding protein 5; KO, knockout; MBH, mediobasal hypothalamus; MTORC1, mechanistic target of rapamycin kinase complex 1; p: phosphorylated; PHLPP: PH domain and leucine rich repeat protein phosphatase; RPS6KB/p70S6K: ribosomal protein S6 kinase; SKP2: S-phase kinase-associated protein 2; SM: soleus muscle; SQSTM1/p62, sequestosome 1; STK11/LKB1: serine/threonine kinase 11; TSC: TSC complex; ULK1: unc-51 like kinase 1; WIPI: WD repeat domain, phosphoinositide interacting; WT: wild type.
Topics & Concepts
AutophagyFKBP5BiologymTORC1Cell biologyNutrient sensingScaffold proteinBAG3Signal transductionGlucocorticoid receptorGlucocorticoidEndocrinologyProtein kinase BBiochemistryApoptosisAutophagy in Disease and TherapyPancreatic function and diabetesCalcium signaling and nucleotide metabolism