Enantioselective β-C(sp<sup>3</sup>)–H arylation of amides<i>via</i>synergistic nickel and photoredox catalysis
Wu Zhang, Xiaomin Shu, Leitao Huan, Buqing Cheng, Haohua Huo
Abstract
synergistic nickel and photoredox catalysis is reported. The C-H bond is activated by a bromine-radical-mediated C-H cleavage. This mild yet straightforward protocol provides arylation products in up to 96% yield and with up to 95% ee.
Topics & Concepts
Enantioselective synthesisNickelCatalysisChemistryPhotoredox catalysisCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryPhotocatalysisRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques