Design, synthesis, stereochemical determination, molecular docking study, in silico pre-ADMET prediction and anti-proliferative activities of indole-pyrimidine derivatives as Mcl-1 inhibitors
Phoebe F. Lamie, John N. Philoppes
Topics & Concepts
ChemistryIn silicoPyrimidineIndole testStereochemistryDocking (animal)Two-dimensional nuclear magnetic resonance spectroscopyIn vitroProton NMRActive siteCombinatorial chemistryEnzymeBiochemistryMedicineNursingGeneCell death mechanisms and regulationComputational Drug Discovery MethodsProtein Kinase Regulation and GTPase Signaling