HPV Integration Can Drive the Formation of Virus–Host Extrachromosomal DNA in Tumors
Alison A. McBride, Elizabeth White
Abstract
Human papillomavirus (HPV)-positive cancer cells contain virus and host DNA and exhibit marked genome instability. In this issue of Cancer Discovery, Akagi and colleagues characterize the remarkably complex landscape of virus-host DNA molecules in HPV-positive cells, providing evidence for diverse integrated and extrachromosomal virus-host hybrid DNAs with the potential to drive clonal evolution. See related article by Akagi et al., p. 910 (4).
Topics & Concepts
Extrachromosomal DNABiologyGenomeVirusDNAHost (biology)VirologyDNA virusGenome instabilityComputational biologyGeneticsGeneDNA damageCervical Cancer and HPV ResearchViral-associated cancers and disordersCancer Genomics and Diagnostics