Metabolic regulation of (−)-epicatechin and the colonic metabolite 2,3-dihydroxybenzoic acid on the glucose uptake, lipid accumulation and insulin signalling in cardiac H9c2 cells
Esther García-Díez, María Elvira López‐Oliva, Jara Pérez‐Jiménez, María Ángeles Martín, Sonia Ramos
Abstract
EC and DHBA decrease lipid accumulation, increase glucose uptake and strengthen the insulin-signalling pathway. EC and DHBA modulate the cardiac glucose uptake and lipid accumulation via AKT and AMPK.
Topics & Concepts
AMPKGlucose uptakeProtein kinase BCD36Insulin receptorCarnitineLipid metabolismAMP-activated protein kinaseBiochemistryChemistryInsulinGlucose transporterBiologyProtein kinase AKinaseSignal transductionEndocrinologyInsulin resistanceReceptorMetabolism, Diabetes, and CancerPhytochemicals and Antioxidant ActivitiesNatural Antidiabetic Agents Studies