Mechanism of DNA Interaction and Translocation by the Replicase of a Circular Rep-Encoding Single-Stranded DNA Virus
Elvira Tarasova, Sonali Dhindwal, Matthew Popp, Sakeenah Hussain, Reza Khayat
Abstract
of PCV2 Rep to be highly mobile. We propose the mobile nature of these domains to be necessary for proper functioning of Reps. We further demonstrate that Reps exhibit basal NTPase activity. Our studies also provide initial insight into the mechanism of RCR.
Topics & Concepts
DNABiologyHelicaseDNA replicationHuman viromeGeneticsCell biologyGenomeRNAGeneAnimal Virus Infections StudiesPlant Virus Research StudiesViral Infections and Immunology Research