Palladium‐Catalyzed Regioselective Synthesis of 2‐SF<sub>5</sub>‐Indenols and Further Derivatizations
Lucas Popek, Murat Cihan, Nicolas Blanchard, Vincent Bizet
Abstract
Abstract A palladium‐catalyzed synthesis of 2‐SF 5 ‐indenols has been developed by reacting commercially available boronic acid derivatives and readily accessible SF 5 ‐alkynes. The present methodology is fully regioselective thanks to the intrinsic polarization of SF 5 ‐alkynes. A selection of downstream functionalizations has been performed to highlight the versatility of 2‐SF 5 ‐indenols and indenones as platforms for the design of more complex SF 5 ‐containing molecules.
Topics & Concepts
RegioselectivityPalladiumChemistryCatalysisCombinatorial chemistryBoronic acidMoleculeOrganic chemistryFluorine in Organic ChemistryCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods