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<i>In Vitro</i> Evaluation of Antifungal Drug Combinations against Multidrug-Resistant Candida auris Isolates from New York Outbreak

Brittany O’Brien, Sudha Chaturvedi, Vishnu Chaturvedi

2020Antimicrobial Agents and Chemotherapy65 citationsDOIOpen Access PDF

Abstract

Since 2016, New York hospitals and health care facilities have faced an unprecedented outbreak of the pathogenic yeast Candida auris . We tested over 1,000 C. auris isolates from affected facilities and found high resistance to fluconazole (MIC &gt; 256 mg/liter) and variable resistance to other antifungal drugs. Therefore, we tested if two-drug combinations are effective in vitro against multidrug-resistant C. auris .

Topics & Concepts

Candida aurisMultiple drug resistanceAntifungal drugsMicrobiologyAntifungalBiologyDrug resistanceIn vitroGeneticsAntifungal resistance and susceptibilityFungal Infections and StudiesSynthesis and Biological Evaluation
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