Concise synthesis of pyrrolo[3,4-c]quinolines via a P(NMe2)3-catalyzed [4 + 2] annulation followed by a Zn/AcOH-mediated reduction–hydroamination–isomerization

Zhengyang Chen, Dan Xiong, Nengzhong Wang, Yufei Zhang, Hui Yao, Jinkun Zhang, Nianyu Huang, Kun Zou

2024Organic Chemistry Frontiers18 citationsDOI

Abstract

A P(NMe2)3-catalyzed [4 + 2] annulation of 2-amino-β-nitrostyrenes and β′-acetoxy allenoates followed by a Zn/AcOH-mediated reduction–hydroamination–isomerization has been developed.

Topics & Concepts

ChemistryAnnulationCatalysisCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsSynthesis and Characterization of Pyrroles

Concise synthesis of pyrrolo[3,4-<i>c</i>]quinolines <i>via</i> a P(NMe<sub>2</sub>)<sub>3</sub>-catalyzed [4 + 2] annulation followed by a Zn/AcOH-mediated reduction–hydroamination–isomerization

Abstract

Topics & Concepts