<scp>Copper‐Mediated</scp> and Catalyzed C—H Bond Amination via Chelation Assistance: Scope, Mechanism and Synthetic Applications
Jiaoli Ma, Xuming Zhou, Penghu Guo, Hui‐Cheng Cheng, Hongbing Ji
Abstract
Comprehensive Summary Nitrogen‐containing compounds are ubiquitously found in the fields of organic chemistry, pharmaceuticals, agrochemicals, medicinal chemistry and functional materials. The C—H bond amination reaction is one of the most straightforward protocols in the C—N bond formation, showing "step" and "atomic" economy. As a catalyst for C—H amination reaction, copper exhibits its unique catalytic properties due to easily accessible oxidation states. The research progress of copper‐catalyzed C—H amination in recent years is summarized. At the same time, reaction mechanisms are also briefly described in representative aminations to provide insights for the development prospects of highly practical and more environmentally benign processes.