The YAP/SERCA2a signaling pathway protects cardiomyocytes against reperfusion-induced apoptosis
Jiankai Zhong, Haichun Ouyang, Sulin Zheng, Zhongzhou Guo, Yuying Chen, Yuan‐Lin Zhong, Wenhao Zhong, Liuer Zuo, Jianhua Lu
Abstract
overexpression on mitochondrial damage and ERS. Overall, our findings reveal that the YAP/SERCA2a pathway attenuates the mitochondrial damage and ERS in response to cardiac I/R injury by regulating the mitochondria-ER communication.
Topics & Concepts
ApoptosisCell biologySignal transductionChemistryBiologyBiochemistryHippo pathway signaling and YAP/TAZCell death mechanisms and regulationPARP inhibition in cancer therapy