Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals
Xin Xu, Ruchao Peng, Qi Peng, Min Wang, Ying Xu, Liu Sheng, Xiaolin Tian, Haiteng Deng, Yimin Tong, Xiaoyou Hu, Jin Zhong, Peiyi Wang, Jianxun Qi, George F. Gao, Yi Shi
Topics & Concepts
PolymeraseRNA polymeraseArenavirusLassa virusBiologyRNA-dependent RNA polymeraseVirologyRNAViral replicationVirusCell biologyChemistryGeneticsGeneIn vitroLymphocytic choriomeningitisCytotoxic T cellViral Infections and Outbreaks ResearchBacillus and Francisella bacterial researchViral gastroenteritis research and epidemiology