SARS-CoV-2 Infection of Microglia Elicits Proinflammatory Activation and Apoptotic Cell Death
Gi Uk Jeong, Jaemyun Lyu, Kyun‐Do Kim, Young Cheul Chung, Gun Young Yoon, Sumin Lee, Insu Hwang, Won-Ho Shin, Junsu Ko, June‐Yong Lee, Young‐Chan Kwon
Abstract
Recent studies reported neurological and cognitive sequelae in patients with COVID-19 months after the viral infection with several symptoms, including ageusia, anosmia, asthenia, headache, and brain fog. Our conclusions raise awareness of COVID-19-related microglia-mediated neurological disorders to develop treatment strategies for the affected patients. We also indicated that HMC3 was a novel human cell line susceptible to SARS-CoV-2 infection that exhibited cytopathic effects, which could be further used to investigate cellular and molecular mechanisms of neurological manifestations of patients with COVID-19.