Hypoxia and the Tumor Microenvironment
Yue Li, Long Zhao, Xiaofeng Li
Abstract
Hypoxia is an important feature of the tumor microenvironment, and is closely associated with cell proliferation, angiogenesis, metabolism and the tumor immune response. All these factors can further promote tumor progression, increase tumor aggressiveness, enhance tumor metastatic potential and lead to poor prognosis. In this review, these effects of hypoxia on tumor biology will be discussed, along with their significance for tumor detection and treatment.
Topics & Concepts
Tumor microenvironmentHypoxia (environmental)AngiogenesisTumor hypoxiaCancer researchImmune systemTumor progressionTumor cellsMedicineBiologyImmunologyCancerChemistryInternal medicineRadiation therapyOxygenOrganic chemistryCancer, Hypoxia, and MetabolismCancer Research and TreatmentsNanoplatforms for cancer theranostics