Efficacy of Computed Tomography-Based Evaluation of Myocardial Extracellular Volume Combined With Red Flags for Early Screening of Concealed Cardiac Amyloidosis in Patients With Atrial Fibrillation
Hirochika Yamasaki, Hidekazu Kondo, Tomoaki Shiroo, Naohiro Iwata, Teruaki Masuda, Taiki Makita, Yuki Iwabuchi, Kota Tanazawa, Masaki Takahashi, Y ocirc ichi Ono, Naoko Ogawa, Taisuke Harada, Kazuki Mitarai, Shuichiro Yamauchi, Masayuki Takano, Nozomi Kodama, Kei Hirota, Miho Miyoshi, Keisuke Yonezu, Katsunori Tawara, Ichitaro Abe, Shotaro Saito, Akira Fukui, Tomoko Fukuda, Hidefumi Akioka, Tetsuji Shinohara, Kumiko Akiyoshi, Yasushi Teshima, Kunio Yufu, Tsutomu Daa, Etsuro Matsubara, Yoshiki Asayama, Mitsuharu Ueda, Naohiko Takahashi
Abstract
BACKGROUND: The prevalence of transthyretin amyloid cardiomyopathy (ATTR-CM) in atrial fibrillation (AF) patients remains unclear. We explored the efficacy of computed tomography-based myocardial extracellular volume (CT-ECV) combined with red flags for the early screening of concealed ATTR-CM in AF patients undergoing catheter ablation. METHODS AND RESULTS: Tc-PYP study, and 6 patients were subsequently diagnosed with wild-type ATTR-CM via cardiac biopsy and genetic testing. CONCLUSIONS: CT-ECV combined with red flags could contribute to the systematic early screening of concealed ATTR-CM in AF patients undergoing catheter ablation.