Arylketones as Aryl Donors in Palladium-Catalyzed Suzuki–Miyaura Couplings
Zhenyu Wang, Biao Ma, Hui Xu, Xing Wang, Xu Zhang, Hui‐Xiong Dai
Abstract
Herein, we report the arylation, alkylation, and alkenylation of aryl ketones via a palladium-catalyzed Suzuki-Miyaura cross-coupling reaction. The use of the pyridine-oxazoline ligand is the key to the cleavage of the unstrained C-C bond. The late-stage arylation of aryl ketones derived from drugs and natural products demonstrated the synthetic utility of this protocol.
Topics & Concepts
ChemistryPalladiumArylCatalysisCombinatorial chemistryMedicinal chemistryOrganic chemistryAlkylCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsSynthetic Organic Chemistry Methods