Is <sup>18</sup>F-FDG PET/CT an Accurate Way to Detect Lymph Node Metastasis in Colorectal Cancer: A Systematic Review and Meta-Analysis
Hamid Dahmarde, Fateme Parooie, Morteza Salarzaei
Abstract
Aims . The purpose of this study was to assess the diagnostic value of 18 F-fluorodeoxy-glucose positron emission tomography/computed tomography (FDG PET/CT) for detection of lymph node (LN) metastasis of colorectal cancer. Material and Methods . A computerized search was performed to determine the relevant articles, published before October 2019. Stata Statistical Software, version 15.0, and Meta-Disc (version 1.4) were used for the meta-analysis. Results . the sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio were 0.65, 0.75, 4.57, and 0.37 respectively. Studies that used SUV max cut-off value (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mo>≤</mml:mo><mml:mn>2.5</mml:mn></mml:math>) demonstrated the best accuracy. Conclusion . 18 F-FDG PET/CT shows a low sensitivity and high specificity for detecting the metastasis of LNs in patients with newly diagnosed colorectal cancer.