Transcripts 202 and 205 of IL-6 confer resistance to Vemurafenib by reactivating the MAPK pathway in BRAF(V600E) mutant melanoma cells
Kun Zhao, Yanrong Lu, Younan Chen, Jingqiu Cheng, Wengeng Zhang
Topics & Concepts
VemurafenibMelanomaCancer researchBiologyMAPK/ERK pathwayDrug resistanceV600EProtein kinase AMutationMEK inhibitorMutantKinaseGeneCell biologyMetastatic melanomaGeneticsMelanoma and MAPK PathwaysCutaneous Melanoma Detection and ManagementComputational Drug Discovery Methods