Co-infusion of CD19-targeting and BCMA-targeting CAR-T cells for treatment-refractory systemic lupus erythematosus: a phase 1 trial
Jingjing Feng, Dawei Huo, Ruimin Hong, Xuexiao Jin, Heng Cao, Mi Shao, Rui Wen, Qiqi Zhang, Mingming Zhang, Shan Fu, Dongrui Wang, Huijun Xu, Guoqing Wei, Jiazhen Cui, Simao Huang, Dawei Cui, Alex H. Chang, Zhihong Liu, Linrong Lu, Jin Lin, Yongxian Hu, He Huang
Topics & Concepts
MedicineAutoantibodyELISPOTImmunologyCytokine release syndromeImmune systemAntibodyB-cell activating factorNeutropeniaInternal medicineImmunosuppressionSystemic lupus erythematosusCD19Adverse effectAutoimmunityLupus erythematosusAntigenRituximabCD8Lupus nephritisAnemiaB cellAutoimmune diseaseEx vivoCD154T cellCytokineClinical endpointBone marrowCohortPeripheral blood cellCD40RashCAR-T cell therapy researchT-cell and B-cell ImmunologyImmune Cell Function and Interaction