Amidation by reactive extrusion for the synthesis of active pharmaceutical ingredients teriflunomide and moclobemide
Matthieu Lavayssiere, Frédéric Lamaty
Abstract
The solventless synthesis of an amide was performed in a twin-screw extruder in the presence of a coupling agent, providing a high yielding and productive method. The reaction conditions were optimized to prepare APIs, teriflunomide and moclobemide.
Topics & Concepts
MoclobemideActive ingredientTeriflunomideChemistryReactive extrusionExtrusionCombinatorial chemistryOrganic chemistryPharmacologyMaterials scienceMedicinePolymerFingolimodHippocampusMetallurgyAntidepressantPsychiatryMultiple sclerosisEndocrinologyChemical Synthesis and AnalysisProtein purification and stabilityAnalytical Chemistry and Chromatography