Sustainable protocol for Cu-catalysed A <sup>3</sup> -coupling under solvent-free conditions
A. Chaturvedi, Vishal Sharma, Ravindra K. Rawal, Manpreet Singh, Virender Singh
Abstract
can be performed in open air, and utilizes only a small amount of a cheap and readily available catalyst (2.5 to 10 mol% CuI). It proficiently produced a variety of biphenylacetylene tethered propargylamines, alkyne tethered dihydroisoquinolines, and N-fused benzimidazoles with excellent regioselectivity.
Topics & Concepts
Protocol (science)Coupling (piping)ChemistryComputer scienceMaterials scienceMedicineMetallurgyPathologyAlternative medicineCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsChemical synthesis and alkaloids