Gastroprotective effects of ginsenoside Rh4 against ethanol-induced gastric mucosal injury by inhibiting the MAPK/NF-κB signaling pathway
Yuqing Wu, Zhiguang Duan, Linlin Qu, Yi Zhang, Chenhui Zhu, Daidi Fan
Abstract
blockade of proinflammatory mitogen-activated protein kinase-nuclear factor κB (MAPK/NF-κB) signaling pathways. Furthermore, ginsenoside Rh4 significantly enhanced the protein expression of B-cell lymphoma gene 2 (Bcl-2), decreased the protein expression of Bcl-2-associated X protein (Bax) and tumor necrosis factor receptor superfamily member 6 (Fas), and inhibited the number of apoptotic cells in gastric tissues. The present work demonstrated that ginsenoside Rh4 exerted a considerable gastroprotective effect against ethanol-induced gastric ulcers in rats.
Topics & Concepts
MAPK/ERK pathwayGinsenosidePharmacologyChemistryNF-κBGinsenoside Rg1EthanolSignal transductionMedicineBiochemistryPathologyGinsengAlternative medicineGinseng Biological Effects and ApplicationsHops Chemistry and ApplicationsMagnolia and Illicium research