Increasing protein stability by engineering the n → π* interaction at the β-turn
Bhavesh Khatri, Puja Majumder, Jayashree Nagesh, Aravind Penmatsa, Jayanta Chatterjee
Abstract
torsion angle. Our results also suggest that amino acid side-chain identity and its rotameric conformation play an important and decisive role in dictating the strength of an n → π* interaction.
Topics & Concepts
Stability (learning theory)Turn (biochemistry)Amino acid residueProtein engineeringChemistryAmino acidProtein structureStructural stabilityBiophysicsComputer sciencePeptide sequenceEngineeringBiochemistryBiologyStructural engineeringMachine learningEnzymeGeneProtein Structure and DynamicsRNA and protein synthesis mechanismsBiochemical and Structural Characterization