Antikinetoplastid SAR study in 3-nitroimidazopyridine series: Identification of a novel non-genotoxic and potent anti-T. b. brucei hit-compound with improved pharmacokinetic properties
Cyril Fersing, Clotilde Boudot, Romain Paoli-Lombardo, Nicolas Primas, Émilie Pinault, Sébastien Hutter, Caroline Castera‐Ducros, Youssef Kabri, Julien Pedron, Sandra Bourgeade‐Delmas, Alix Sournia‐Saquet, Jean-Luc Stigliani, Alexis Valentin, Amaya Azqueta, Damián Muruzabal, Alexandre Destère, Susan Wyllie, Alan H. Fairlamb, Sophie Corvaisier, Marc Since, Aurélie Malzert‐Fréon, Carole Di Giorgio, Pascal Rathelot, Nadine Azas, Bertrand Courtioux, Patrice Vanelle, Pierre Verhaeghe
Topics & Concepts
ChemistryPharmacophoreTrypanosoma bruceiPharmacokineticsPharmacologyIn vitroImidazopyridineStereochemistryLipinski's rule of fiveBiochemistryIn silicoGeneMedicineResearch on Leishmaniasis StudiesTrypanosoma species research and implicationsSynthesis and Biological Evaluation