Development of hetero-triaryls as a new chemotype for subtype-selective and potent Sirt5 inhibition
Carina Glas, Eli Naydenova, Severin Lechner, Nathalie Wössner, Liu Yang, Johannes C. B. Dietschreit, Hongyan Sun, Manfred Jung, Bernhard Küster, Christian Ochsenfeld, Franz Bracher
Topics & Concepts
ChemistryIC50BiochemistryLead compoundStereochemistryIn vitroPharmacologyBiologySirtuins and Resveratrol in MedicinePARP inhibition in cancer therapyCalcium signaling and nucleotide metabolism