Wnt7a Counteracts Cancer Cachexia
Manuel Schmidt, Christine Poser, Julia von Maltzahn
Abstract
mouse model based on C26 colon carcinoma cells. Wnt7a has a dual role in cachectic skeletal muscle; that is, it effectively counteracts muscle wasting through activation of the anabolic AKT/mTOR pathway and, furthermore, reverts the loss of muscle stem cell functionality due to cancer cachexia, making Wnt7a a promising candidate for an ameliorative treatment of cancer cachexia.
Topics & Concepts
CachexiaCancer cachexiaCancerMedicineCancer researchOncologyInternal medicineMuscle Physiology and DisordersNutrition and Health in AgingGDF15 and Related Biomarkers