Thermo-Responsive Cellulose Hydrogels: A Flourishing Frontier in Material Design
Kai He, Jiaying Qu, Yu Cao
Abstract
Thermo-responsive cellulose-based hydrogels have emerged as a transformative class of biomaterials, offering significant potential in diverse applications. This review provides a systematic examination of the diverse landscape of these hydrogels, categorized by their underlying responsive mechanisms. We explore the inherent thermo-responsiveness of cellulose derivatives, including methylcellulose (MC) and hydroxypropyl methylcellulose (HPMC), and elucidate their unique phase transition behaviors. Furthermore, we delve into cellulose hydrogels functionalized with thermo-responsive side chains, focusing on poly (N-isopropylacrylamide) (PNIPAM) and its synergistic blends. We also highlight the emerging field of multi-responsive cellulose hydrogels, emphasizing their unique capabilities and potential applications across various sectors. By providing a comprehensive understanding of the design, development, and application of these versatile materials, this review aims to serve as a valuable resource for researchers seeking to harness the potential of thermo-responsive cellulose-based hydrogels in advancing biomaterials, biomedicine, and beyond. This review offers a timely and comprehensive overview of the state-of-the-art in thermo-responsive cellulose hydrogels, guiding future research and innovation in this exciting field.