Potential effects of bisphenol A on diabetes mellitus and its chronic complications: A narrative review
Wei Jiang, Kaixi Ding, Wenjie Huang, Xu Feng, Ming Lei, Rensong Yue
Abstract
Diabetes mellitus (DM) is a metabolic disease caused by multiple factors such as genetics, environment, and lifestyle. Bisphenol A (BPA), as one of the most common endocrine-disrupting chemicals (EDCs), has been strongly implicated in the development of type 2 diabetes mellitus (T2DM). BPA exposure is associated with target organ damage in DM and may exacerbate the progression of some chronic complications of DM. This paper reviews relevant epidemiological, in vivo, and in vitro studies to better understand BPA's potential risk associations and pathological mechanisms in several chronic diabetic complications.
Topics & Concepts
Diabetes mellitusMedicineType 2 Diabetes MellitusEndocrine systemEpidemiologyBenzhydryl compoundsPathologicalBioinformaticsDiseaseBisphenol AEndocrine diseaseInternal medicineEndocrinologyBiologyChemistryHormoneEpoxyOrganic chemistryEffects and risks of endocrine disrupting chemicalsAnimal testing and alternativesComputational Drug Discovery Methods