Formulation, characterization, optimization, and <i>in-vivo</i> performance of febuxostat self-nano-emulsifying system loaded sublingual films
Basant A. Habib, Amina S. Abd El-Samiae, Boushra El-Houssieny, Randa Tag
Abstract
than marketed tablets. Relative bioavailability of O-SF compared to the marketed tablet was found to be 240.6%. This confirms the achievement of the study aims of improving dissolution rate and bioavailability of FXS using a patient-wise convenient formula.
Topics & Concepts
BioavailabilityMaterials scienceSolubilityFactorial experimentPolyethylene glycolPlasticizerDissolutionDissolution testingCmaxPolyvinylpyrrolidoneFolding enduranceChromatographyPolymerChemistryPharmacologyComposite materialMathematicsMedicineOrganic chemistryEthyl cellulosePolymer chemistryStatisticsDrug Solubulity and Delivery SystemsAdvanced Drug Delivery SystemsAnalytical Methods in Pharmaceuticals