Ruscogenin attenuates cartilage destruction in osteoarthritis through suppressing chondrocyte ferroptosis via Nrf2/SLC7A11/GPX4 signaling pathway
Qing Ruan, Cuijie Wang, Yunfeng Zhang, Jiayang Sun
Topics & Concepts
MMP3ChondrocyteIn vivoGene knockdownChemistryInflammationDownregulation and upregulationMatrix metalloproteinaseGPX4Cell biologyOsteoarthritisIn vitroCartilageCancer researchPharmacologyOxidative stressImmunologyApoptosisMedicineBiologyBiochemistryGene expressionPathologyAnatomySuperoxide dismutaseGeneAlternative medicineBiotechnologyGlutathione peroxidaseCancer-related molecular mechanisms researchCircular RNAs in diseasesOsteoarthritis Treatment and Mechanisms