Creeping fat-derived mechanosensitive fibroblasts drive intestinal fibrosis in Crohn’s disease strictures
Khristian E. Bauer-Rowe, Benjamin Pham, Michelle Griffin, Norah E. Liang, Alexia Kim, John Lu, Michael Januszyk, Jason Guo, Stefania De Santis, Yue Xing, Aleksandr Prystupa, Ikjot Sidhu, E Suh, Deshka S. Foster, Maria Korah, Alka Goyal, Derrick C. Wan, Jeffrey A. Norton, Daniel Delitto, Theresa T. Pizarro, Shruti Naik, Jeong S. Hyun, Heather E. Talbott
Topics & Concepts
BiologyFibrosisAdipose tissueExtracellular matrixFibroblastStromal cellPathologyMyofibroblastCell biologyMechanosensitive channelsMesenchymal stem cellFibrillinStromaLumen (anatomy)ElastinDownregulation and upregulationInflammationExtracellularIleumCancer researchPhenotypeIntestinal mucosaDiseaseInflammatory bowel diseaseMatrix metalloproteinaseAnatomySmall intestineCancer-Associated FibroblastsFibroblast Growth Factor ResearchCancer Cells and MetastasisIL-33, ST2, and ILC Pathways