Magnetic resonance imaging of tumor-associated-macrophages (TAMs) with a nanoparticle contrast agent
Junhan Zhou, Vijaykumar S. Meli, Esther Yu-Tin Chen, Rohan Kapre, Raji R. Nagalla, Wenwu Xiao, Alexander D. Borowsky, Kit S. Lam, Wendy F. Liu, Angelique Y. Louie
Abstract
studies. The TAMs demonstrate M2-like function and secrete Arg-1 but not iNOS. Uptake by these M2-like TAMs is validated by immunohistochemistry. SDIO show promise as a valuable addition to the toolkit of imaging probes targeted to different biomarkers for TAMs.
Topics & Concepts
Magnetic resonance imagingContrast (vision)NanoparticleNuclear magnetic resonanceMaterials scienceMRI contrast agentNanotechnologyMedicineRadiologyOpticsPhysicsImmune cells in cancerNanoplatforms for cancer theranosticsNanoparticle-Based Drug Delivery