Single-cell analysis pinpoints distinct populations of cytotoxic CD4 <sup>+</sup> T cells and an IL-10 <sup>+</sup> CD109 <sup>+</sup> T <sub>H</sub> 2 cell population in nasal polyps
Junjie Ma, Christopher A. Tibbitt, Susanna Kumlien Georén, Murray Christian, Ben Murrell, Lars‐Olaf Cardell, Claus Bachert, Jonathan M. Coquet
Abstract
Transcriptional profiling pinpoints the heterogeneity of T helper cells in human nasal polyps at the clonal level.
Topics & Concepts
Cytotoxic T cellGATA3Nasal polypsImmunologyBiologyInnate lymphoid cellPopulationFlow cytometryCTL*Molecular biologyAntigenImmune systemMedicineCD8Innate immune systemGeneTranscription factorGeneticsIn vitroEnvironmental healthIL-33, ST2, and ILC PathwaysAsthma and respiratory diseasesImmune Cell Function and Interaction