Preservation of recipient plasma sphingosine-1-phosphate levels reduces transfusion-related acute lung injury
Vanessa Hsing, Han Qi Zhao, Martin Post, Dana V. Devine, Mark J. McVey
2024American Journal of Physiology-Lung Cellular and Molecular Physiology10 citationsDOIOpen Access PDF
Abstract
Transfusion-related acute lung injury (TRALI) though relatively rare represents a severe lung injury. The sphingolipid sphingosine-1-phosphate (S1P) regulates the severity of platelet-mediated TRALI. Female platelet transfusion recipient plasmas or stored platelets from female donors have higher S1P levels than males, which reduces TRALI. Cold storage of murine platelets preserves platelet-S1P, which reduces TRALI in platelet-transfused recipients.
Topics & Concepts
Transfusion-related acute lung injurySphingosine-1-phosphateSphingosineMedicinePhosphateLungIntensive care medicineInternal medicineChemistryBiochemistryPulmonary edemaReceptorHemoglobin structure and functionSphingolipid Metabolism and SignalingErythrocyte Function and Pathophysiology