Drug–drug cocrystals of anticancer drugs erlotinib–furosemide and gefitinib–mefenamic acid for alternative multi-drug treatment
Christy P. George, Shridhar H. Thorat, Parth S. Shaligram, P. R. Suresha, Rajesh G. Gonnade
Abstract
Drug–drug cocrystals of anticancer drugs erlotinib and gefitinib with furosemide and mefenamic acid, respectively, have been synthesized, characterized and their solubilities and dissolution rates were correlated with crystal structures.
Topics & Concepts
Mefenamic acidErlotinibDrugGefitinibFurosemidePharmacologyErlotinib HydrochlorideMedicineChemistryCancerInternal medicineEpidermal growth factor receptorCrystallography and molecular interactionsCrystal structures of chemical compoundsPhenothiazines and Benzothiazines Synthesis and Activities