Cobalt-Catalyzed (<i>E</i>)-Selective Hydrosilylation of 1,3-Enynes for the Synthesis of 1,3-Dienylsilanes
Degong Kong, Bowen Hu, Min Yang, Haiping Xia, Dafa Chen
Abstract
Two types of regio- and stereoselective hydrosilylation reactions of 1,3-enynes catalyzed by Co complexes were developed. Dppf-CoCl2 is applicable for 3,4-hydrosilylation of 4-aryl-substituted 1,3-enynes, while Xantphos-CoCl2 is suitable for 4,3-hydrosilylation of 4-alkyl-substituted 1,3-enynes. Various functional groups are tolerated, and the produced 1,3-dienylsilanes can participate in several valuable transformations.
Topics & Concepts
HydrosilylationChemistryXantphosCatalysisCobaltArylStereoselectivityAlkylMedicinal chemistryStereochemistryOrganic chemistryOrganoboron and organosilicon chemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization Methods