Litcius/Paper detail

PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease

Ariamala Gopalsamy, Ann Aulabaugh, Amey Barakat, Kevin Beaumont, Shawn Cabral, Daniel P. Canterbury, Agustin Casimiro‐Garcia, Jeanne S. Chang, Ming Z. Chen, Chulho Choi, Robert L. Dow, Olugbeminiyi Fadeyi, Xidong Feng, Scott P. France, Roger M. Howard, Jay M. Janz, J. Jasti, Reema Jasuja, Lyn H. Jones, Amanda King‐Ahmad, Kelly M. Knee, Jeffrey T. Kohrt, Chris Limberakis, Spiros Liras, Carlos A. Martínez, Kim F. McClure, Arjun Narayanan, Jatin Narula, Jonathan J. Novak, Thomas N. O’Connell, Mihir D. Parikh, David W. Piotrowski, Olga Plotnikova, Ralph P. Robinson, Parag V. Sahasrabudhe, Raman Sharma, Benjamin A. Thuma, Dipy M. Vasa, Liuqing Wei, Anne Wenzel, Jane M. Withka, Jun Xiao, Hatice G. Yayla

2020Journal of Medicinal Chemistry43 citationsDOIOpen Access PDF

Abstract

(PF-07059013) has advanced to phase 1 clinical trials.

Topics & Concepts

ChemistryHemoglobinSickle cell anemiaDeoxygenated HemoglobinCellRed blood cellMutationHemoglobin sPharmacologyBiochemistryGeneMedicineHemoglobinopathies and Related DisordersHemoglobin structure and functionIron Metabolism and Disorders
PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease | Litcius