Impaired formation of high-order gephyrin oligomers underlies gephyrin dysfunction-associated pathologies
Seungjoon Kim, Mooseok Kang, Dongseok Park, Ae-Ree Lee, Heinrich Betz, Jaewon Ko, Iksoo Chang, Ji Won Um
Abstract
receptors and neuroligin-2 in mouse brain; it also failed to normalize deficits in GABAergic synapse maintenance and neuronal hyperactivity observed in hippocampal dentate gyrus-specific gephyrin-deficient mice. Our results provide insights into biochemical, cell-biological, and network-activity effects of the pathogenic G375D mutation.
Topics & Concepts
GephyrinInhibitory postsynaptic potentialBiologySynapseSynaptogenesisDentate gyrusMutationCell biologyNeuroscienceHippocampal formationGlycine receptorGeneticsGeneGlycineAmino acidPorphyrin and Phthalocyanine ChemistryPorphyrin Metabolism and DisordersHeme Oxygenase-1 and Carbon Monoxide