Synergistic Noncovalent Catalysis Facilitates Base-Free Michael Addition
Jianzhu Wang, Tom A. Young, Fernanda Duarte, Paul J. Lusby
Abstract
units. Using a second noncovalent reagent-commercially available 18-crown-6-facilitates catalytic base-free addition of several challenging Michael partners. The cage's microenvironment also promotes high diastereoselectivity compared to a conventional base-catalyzed reaction.
Topics & Concepts
ChemistryDeprotonationNucleophileElectrophileMichael reactionCatalysisNon-covalent interactionsReagentCombinatorial chemistryBase (topology)OrganocatalysisProtonationStereochemistryOrganic chemistryMoleculeIonHydrogen bondEnantioselective synthesisMathematicsMathematical analysisSupramolecular Chemistry and ComplexesMetal-Organic Frameworks: Synthesis and ApplicationsMolecular Sensors and Ion Detection