The Ankyrin Repeat Protein RARP-1 Is a Periplasmic Factor That Supports <i>Rickettsia parkeri</i> Growth and Host Cell Invasion
Allen G. Sanderlin, Ruth E. Hanna, Rebecca L. Lamason
Abstract
ankyrin repeat protein RARP-1, which is conserved across the genus but has not yet been functionally characterized. Earlier work had suggested that RARP-1 is secreted into the host cytoplasm. However, the results from this work demonstrate that R. parkeri RARP-1 resides in the periplasm and is important both for invasion of host cells and for growth in the host cell cytoplasm. These results reveal RARP-1 as a novel regulator of the rickettsial life cycle.
Topics & Concepts
BiologyPeriplasmic spaceRickettsiaAnkyrin repeatVirologyHost (biology)MicrobiologyGeneticsEscherichia coliGeneVirusVector-borne infectious diseasesEndoplasmic Reticulum Stress and DiseaseTrypanosoma species research and implications