High cholesterol and 27-hydroxycholesterol contribute to phosphorylation of tau protein by impairing autophagy causing learning and memory impairment in C57BL/6J mice
Tao Wang, Xiaona Zhang, Yushan Wang, Wen Liu, Lijing Wang, Ling Hao, Mengwei Ju, Rong Xiao
Topics & Concepts
Downregulation and upregulationCYP27A1AutophagySmall hairpin RNAPhosphorylationTau proteinEndocrinologyPI3K/AKT/mTOR pathwayGSK-3BiologyInternal medicineChemistryCholesterolCell biologySignal transductionBiochemistryMedicineAlzheimer's diseaseRNAGeneApoptosisDiseaseNuclear Receptors and SignalingGenetics and Neurodevelopmental DisordersAutophagy in Disease and Therapy