Physiologically Based Pharmacokinetic Modeling of Oral Absorption, pH, and Food Effect in Healthy Volunteers to Drive Alpelisib Formulation Selection
Monika Gajewska, Lars Blumenstein, Alexandros Kourentas, Martin Mueller‐Zsigmondy, Sebastien Lorenzo, Angela Sinn, Maria Velinova, Tycho Heimbach
Topics & Concepts
Physiologically based pharmacokinetic modellingBioequivalenceCmaxPharmacokineticsBioavailabilityPharmacologyAbsorption (acoustics)DrugMedicineChemistryMaterials scienceComposite materialDrug Transport and Resistance MechanismsRenal Transplantation Outcomes and TreatmentsPharmacogenetics and Drug Metabolism