New-Onset Diabetes in Covid-19
Francesco Rubino, Stephanie A. Amiel, Paul Zimmet, George Alberti, Stefan R. Bornstein, Robert H. Eckel, Geltrude Mingrone, Bernhard O. Boehm, Mark E. Cooper, Zhonglin Chai, Stefano Del Prato, Linong Ji, David Hopkins, William H. Herman, Kamlesh Khunti, Jean Claude Mbanya, Éric Renard
Abstract
There is a bidirectional relationship between Covid-19 and diabetes. On the one<br/>hand, diabetes is associated with an increased risk of severe Covid-19. On the other hand, newonset diabetes and severe metabolic complications of preexisting diabetes, including diabetic ketoacidosis and hyperosmolarity for which exceptionally high doses of insulin are warranted, have been observed in patients with Covid-19.1-3<br/>These manifestations of diabetes pose challenges in clinical management and suggest a complex pathophysiology of Covid-19–related diabetes.