Zng1 is a GTP-dependent zinc transferase needed for activation of methionine aminopeptidase
Miriam Pasquini, Nicolas Grosjean, Kim Hixson, Carrie Nicora, Estella F. Yee, Mary Lipton, Ian K. Blaby, John D. Haley, Crysten E. Blaby‐Haas
Abstract
to apo-Map1p, but unlike characterized copper chaperones, transfer is dependent on GTP hydrolysis. Proteomics reveal mis-regulation of the Zap1p transcription factor regulon because of loss of ZNG1 and Map1p activity, suggesting that Zng1p is required to avoid a compounding effect of Map1p dysfunction on survival during Zn limitation.
Topics & Concepts
TransferaseGTP'MethionineAminopeptidaseZincChemistryBiochemistryMethyltransferaseEnzymeCell biologyBiologyAmino acidMethylationLeucineGeneOrganic chemistryPeptidase Inhibition and AnalysisTrace Elements in HealthPneumocystis jirovecii pneumonia detection and treatment