Peripheral nervous system manifestations of MOG antibody associated disease
Pranjal Gupta, Pritikanta Paul, Vyanka Redenbaugh, Yong Guo, Claudia F. Lucchinetti, Yahya Abdulrahman, Abhigyan Datta, Shailee Shah, Christopher J. Klein, Sean J. Pittock, Eoin P. Flanagan, Divyanshu Dubey
Abstract
Recent studies have reported the involvement of peripheral nervous system (PNS) in association with MOG-IgG, including isolated neuropathies. In this retrospective study we characterized the PNS involvement in MOG antibody associated disease (MOGAD). Six out of 215 MOGAD patients had PNS involvement (all polyradiculopathy) that occurred concurrently with a CNS demyelinating episode. We also demonstrated MOG expression in healthy human controls' proximal nerve root. Nine patients with true-positive MOG-IgG1 had PNS involvement temporally unrelated to a CNS demyelinating event. All these patients had an alternate etiology of PNS involvement. Isolated peripheral neuropathy is not a feature of MOGAD, but inflammatory nerve root involvement can occur concurrently with CNS demyelinating events.