Synthesis of novel tryptanthrin derivatives as dual inhibitors of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase
Yuanyuan Li, Shengnan Zhang, Rong Wang, Menghan Cui, Wei Liu, Qing Yang, Chunxiang Kuang
Topics & Concepts
ChemistryIndoleamine 2,3-dioxygenaseNatural productDioxygenaseTryptophanInhibitory postsynaptic potentialLead compoundStructure–activity relationshipBiochemistryDrug discoveryPharmacologyStereochemistryIn vitroEnzymeBiologyAmino acidNeuroscienceTryptophan and brain disordersBipolar Disorder and TreatmentAdenosine and Purinergic Signaling