Manganese-Catalyzed Enantioselective Hydrogenation of Simple Ketones Using an Imidazole-Based Chiral PNN Tridentate Ligand
Fei Ling, Jiachen Chen, Sanfei Nian, Huacui Hou, Xiao Yi, Feifei Wu, Min Xu, Weihui Zhong
Abstract
A series of Mn(I) catalysts containing imidazole-based chiral PNN tridentate ligands with controllable ‘side arm’ groups have been established, enabling the inexpensive base-promoted asymmetric hydrogenation of simple ketones with outstanding activities (up to 8200 TON) and good enantioselectivities (up to 88.5% ee). This protocol features wide substrate scope and functional group tolerance, thereby providing easy access to a key intermediate of crizotinib.
Topics & Concepts
ChemistryImidazoleEnantioselective synthesisCatalysisManganeseCombinatorial chemistryLigand (biochemistry)Functional groupSubstrate (aquarium)Organic chemistryReceptorOceanographyPolymerGeologyBiochemistryAsymmetric Hydrogenation and CatalysisSurface Chemistry and CatalysisCatalysis for Biomass Conversion