Adjunctive Rifampin Following Debridement and Implant Retention for Staphylococcal Prosthetic Joint Infection: Is it Effective if not Combined With a Fluoroquinolone?
Nicolás Cortés-Penfield, Angela Hewlett, André C. Kalil
Abstract
Whether rifampin benefits retained staphylococcal prosthetic joint infection is unsettled. In a meta-analysis of 8 studies, we found greater clinical cure with fluoroquinolone-rifampin vs all other regimens (odds ratio [OR], 2.68; 95% CI, 1.43-5.02), but no greater cure with other rifampin combinations vs regimens without rifampin (OR, 1.22; 95% CI, 0.79-1.88).
Topics & Concepts
MedicineDebridement (dental)SurgeryStaphylococcal infectionsJoint infectionsAntibioticsOdds ratioImplantInternal medicineStaphylococcus aureusArthroplastyMicrobiologyPeriprostheticBacteriaGeneticsBiologyOrthopedic Infections and TreatmentsAntimicrobial Resistance in StaphylococcusAntibiotics Pharmacokinetics and Efficacy