Fabrication of Durably Antibacterial Cotton Fabrics by Robust and Uniform Immobilization of Silver Nanoparticles via Mussel-Inspired Polydopamine/Polyethyleneimine Coating
Gongyan Liu, Jun Xiang, Qiongfen Xia, Kaijun Li, Hui Yan, Ling Yu
Abstract
Bacterial contamination of cotton dressing can potentially cause wound infection. To solve this problem, stable and uniform decoration of silver nanoparticles (AgNPs) onto cotton fabrics is a promising strategy to endow antibacterial activity to prevent wound infection. Herein, a facile codeposition of polydopamine (PDA)/polyethyleneimine (PEI) was performed on cotton fabrics for uniformly cross-linking gallic acid (GA)-stabilized silver nanoparticles (GA@AgNPs) via Michael addition and hydrogen bonding interactions. The as-prepared GA@AgNPs/PDA–PEI-coated cotton fabrics possessed a negatively charged surface because of the high-density GA on AgNPs, showing low cytotoxicity, hemocompatibility, and hemostatic ability. Because of its stable, uniform, and anionic interface composed of GA@AgNPs, this GA@AgNPs/PDA–PEI coating could effectively resist bacterial adhesion by electrostatic repulsion and also kill the attached bacteria through sustained Ag+ release, exhibiting strong, broad-spectrum, and durable antibacterial activities toward bacteria. Therefore, these GA@AgNPs/PDA–PEI-coated cotton fabrics show great potential for clinical application as antibacterial wound dressings.